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AMPLIFICATION OF BIOLOGICAL TARGETS VIA ON-CHIP CULTURE FOR BIOSENSING

United States Patent Application

20150024414
A1
View the Complete Application at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.
Harper, Jason C. (Rio Rancho, NM), Edwards, Thayne L. (Albuquerque, NM), Carson, Bryan (Tijeras, NM), Finley, Melissa (Albuquerque, NM), Arndt, William (Albuquerque, NM)
Sandia Corporation (Albuquerque NM)
14/ 157,378
January 16, 2014
STATEMENT OF GOVERNMENT INTEREST [0002] This invention was developed under Contract DE-AC04-94AL85000 between Sandia Corporation and the U.S. Department of Energy. The U.S. Government has certain rights in this invention.