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ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL OR SOURCE OF A BIOLOGICAL MATERIAL

United States Patent Application

20140274758
A1
View the Complete Application at the US Patent & Trademark Office
Idaho National Laboratory - Visit the Technology Transfer and Commercialization Office Website
A sample of a biological material having individual-specific antibodies is contacted with an array of less than about 200 proteins on a support to bind some of the individual-specific antibodies to the proteins of the array to form immune complexes. A detection agent with an interacting protein for conjugation to a marker is applied to the array to detect the immune complexes and obtain an antibody profile, which is compared to a known antibody profile obtained from an individual. The array may further include control spots including human IgG to form control complexes and volume assessment spots including volume determination proteins to form volume complexes. Intensity of the control complexes may be detected to determine if results of the identifying are complete. Intensity of the volume complexes may be detected to determine if a volume of the sample is sufficient for an accurate result.
Apel, William A. (Jackson, WY), Thompson, Vicki S. (Idaho Falls, ID), Lacey, Jeffrey A. (Idaho Falls, ID), Park, Shawna (Atlanta, GA)
13/ 832,406
March 15, 2013
GOVERNMENT RIGHTS [0001] This invention was made with government support under Contract Number DE-AC07-05ID14517 awarded by the United States Department of Energy. The government has certain rights in the invention. CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application is related to U.S. patent application Ser. No. (Docket No. 63077.8050) for COMPUTING SYSTEMS, COMPUTER-READABLE MEDIA AND METHODS OF ANTIBODY PROFILING, filed concurrently herewith, U.S. patent application Ser. No. 12/883,002, filed Sep. 15, 2010, for "IDENTIFICATION OF DISCRIMINANT PROTEINS THROUGH ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL," and U.S. patent application Ser. No. 12/586,109, filed Sep. 17, 2009, for "IDENTIFICATION OF DISCRIMINANT PROTEINS THROUGH ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL," the entire contents for each of which are incorporated herein by this reference.