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Multinozzle Emitter Arrays for Ultrahigh-Throughput Nanoelectrospray Mass Spectrometry

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole. The present invention also provides for a fully integrated separation of proteins and small molecules on a silicon chip before the electrospray mass spectrometry analysis.
Wang, Daojing (Moraga, CA), Mao, Pan (Fremont, CA), Wang, Hung-Ta (Tuscaloosa, AL), Yang, Peidong (Kensington, CA)
14/ 137,840
December 20, 2013
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention was made with government support under Contract Nos. DE-AC02-05CH11231 awarded by the U.S. Department of Energy and Grant R21GM077870 awarded by the National Institutes of Health. The government has certain rights in the invention.