The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.
FEDERAL FUNDING LEGEND
 This invention was made with government support under 5DP1OD000277, awarded by the Department of Energy, 5R01AI041599 awarded by the National Institutes of Health, and 5P41RR012408 awarded by the National Institutes of Health. The government has certain rights in the invention.