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Targeted Self-Assembly of Functionalized Carbon Nanotubes on Tumors

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Provided herein are methods for delivering a molecule in situ to a cell and for treating a cancer via the in situ delivery. The methods comprise contacting or administering to the cell, as two separate components, a morpholino oligonucleotide comprising a targeting moiety followed by a single wall nanotube construct comprising second morpholino oligonucleotides complementary to the first morpholino oligonucleotides and one or both of a therapeutic or diagnostic payload molecule linked to the single wall nanotube construct. Upon self-assembly of a single wall nanotube complex via hybridization of the first morpholino and second complementary morpholino oligonucleotides at the cell, the payload molecule is delivered. Also provided is the two component self-assembly single wall nanotube system and the single wall nanotube construct comprising the second component.
Scheinberg, David A. (New York, NY), McDevitt, Michael R. (Bronx, NY), Villa, Carlos H. (Philadelphia, PA), Mulvey, J. Justin (New York, NY)
14/ 318,112
June 27, 2014
FEDERAL FUNDING LEGEND [0002] This invention was made with government support under grants PO1 CA33049, RO1 CA55349, R21CA128406, and GM07739 awarded by the National Institutes of Health and grant DE-SC0002456 awarded by the U.S. Department of Energy. The government has certain rights in the invention.