The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing such enzymes, as well as methods of their use, for example to produce malonyl semialdehyde and downstream products thereof, such as 3-hydroxypropionic acid and derivatives thereof.
ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT
 This invention was made with United States Government support under contract GO 13144 awarded by the Department of Energy. The United States Government has certain rights in this invention.