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NON-CATALYTIC DOMAIN TARGETS IN MATRIX METALLOPROTEASE PROTEINS FOR CANCER THERAPIES

United States Patent Application

20150079071
A1
View the Complete Application at the US Patent & Trademark Office
The present invention provides compositions and methods for inhibiting MMPs, especially MMP-3, MMP-9 and MMP-14. The invention relates to the field of diagnostic and prognostic methods of human cancers, especially breast cancer and the field of matrix metalloproteases, as targets for diagnostics and therapeutics.
Bissell, Mina J. (Berkeley, CA), Nelson, Celeste M. (Princeton, NJ), Mori, Hidetoshi (Albany, CA), Correia, Ana Luisa Pinto (Lamego, PT), Chen, Emily (Stony Brook, NY)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
14/ 094,702
December 2, 2013
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention was made with government support under Contract No. DE-AC02-05CH1123 awarded by the U.S. Department of Energy, Office of Biological and Environmental Research and under Contract No. W81XWH0810736 awarded by the U.S. Department of Defense, and under Grant Nos. CA064786, CA057621, CA140663, CA112970, CA143233, and CA143836 awarded by the National Cancer Institute of the National Institutes of Health. The government has certain rights in the invention.