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ASSESSING ENDOTHELIAL FUNCTION USING A BLOOD PRESSURE CUFF

United States Patent Application

20140128747
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Methods and apparatus are provided for assessing endothelial function in a mammal. The methods involve applying to the artery a substantially constant external pressure, where the pressure is provided via a cuff adjacent to and/or around a region of the mammal's body; determining, over the course of one or more cardiac cycles, changes in pressure in the cuff resulting from cardiac activity of the mammal to establish a baseline value for a parameter related to endothelial function in the mammal; applying a stimulus to the mammal; determining, over the course of one or more cardiac cycles, changes in pressure in the cuff resulting from cardiac activity of the mammal to establish a stimulus-effected value for a parameter related to endothelial function in the mammal; wherein differences in the baseline value and the stimulus-effected value provide a measure of endothelial function in the mammal.
Maltz, Jonathan S. (Oakland, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
14/ 008,299
April 26, 2012
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.