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Cell Modified in the Expression of a Nucleotide Sugar Transporter

United States Patent Application

20150082494
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a genetically modified eukaryotic host cell comprising (a) a gene encoding a first nucleotide sugar transporter (NST) operably linked to a promoter, wherein the gene and/or the promoter is heterologous to the cell, and/or (b) a native gene encoding a second NTS is disrupted and/or a promoter of the native gene is disrupted. Such modified cells can be altered in the production of polysaccharide and/or glycopeptides. The present invention also provides for methods of making or using such modified cells.
Scheller, Henrik Vibe (Millbrae, CA), Rautengarten, Carsten (Oakland, CA), Ebert, Berit (Oakland, CA), Heazlewood, Joshua L. (Berkeley, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND CA)
14/ 306,183
June 16, 2014
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.