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MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS

United States Patent Application

20140330032
A1
View the Complete Application at the US Patent & Trademark Office
Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
Lynch, Michael D. (Durham, NC), Lipscomb, Tanya E.W. (Boulder, CO), Trahan, Ashley D, (Hillsborough, NC), Singh, Amarjeet (Kirkland, WA), Wolter, Travis (Denver, CO)
14/ 006,014
March 22, 2012
STATEMENT AS TO FEDERALLY SPONSORED RESEARCH [0002] This invention was made with Government support under DE-AR0000088 awarded by the United States Department of Energy. The Government has certain rights in this invention.