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United States Patent Application

View the Complete Application at the US Patent & Trademark Office
The invention provided herein relates to sequence determinants that elicit certain levels of gene expression and methods for obtaining engineered ligand-responsive gene switches comprising these sequence determinants. More particularly, the invention provided herein relates to molecular building blocks (i.e., discrete nucleotide sequences), synthetic ligand-responsive gene switches comprising an assembly of these molecular building blocks, and methods of using synthetic ligand-responsive gene switches as customizable and controllable expression systems and sensors.
Kiley, Patricia J. (Middleton, WI), Park, Dan M. (Dublin, CA)
14/ 597,466
January 15, 2015
STATEMENT REGARDING FEDERALLY FUNDED RESEARCH [0002] This invention was made with government support under GM045844 awarded by the National Institutes of Health and DE-FC02-07ER64494 and DE-FG02-04ER25627 awarded by the US Department of Energy. The government has certain rights in the invention.