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POSITRON EMISSION TOMOGRAPHY PROBE TO MONITOR SELECTED SUGAR METABOLISM IN VIVO

United States Patent Application

*** PATENT GRANTED ***
20150133777
9,592,309
A1
View the Complete Application at the US Patent & Trademark Office
The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.
Witte, Owen (Sherman Oaks, CA), Clark, Peter M. (Los Angeles, CA), Castillo, Blanca Graciela Flores (Van Nuys, CA), Jung, Michael E. (Los Angeles, CA), Evdokimov, Nikolai M. (Los Angeles, CA)
14/ 399,701
May 9, 2013
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This work was supported by NCI Cancer Education Grant R25 CA 098010 from the National Cancer Institute and by grant DE-SC0001249 from the Department of Energy. The Federal Government has certain rights in this invention.