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Host Cells and Methods for Oxidizing Aromatic Amino Acids

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a method of producing an oxidation product of an aromatic amino acid in a genetically modified host cell. The method comprises culturing the genetically modified host cell under a suitable condition such that the culturing results in the genetically modified host cell producing oxidation product of an aromatic amino acid. The host cell comprises an enzyme capable of catalyzing the oxidation of aromatic amino acid. In some embodiments, the host cell is capable of biosynthesizing BH4 or MH4 from GTP.
Lee, Taek Soon (Albany, CA), Satoh, Yasuharu (Sapporo-shi, JP), Keasling, Jay D. (Berkeley, CA)
The Regents of the University of California (Oakland CA)
14/ 042,270
September 30, 2013
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention described and claimed herein was made utilizing funds supplied by the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The government has certain rights in this invention.