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Engineering Microorganisms to Increase Ethanol Production by Metabolic Redirection

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting organisms that have been genetically modified to allow the production of ethanol at a high yield by redirecting carbon flux at key steps of central metabolism.
Deng, Yu (West Lebanon, NH), Olson, Daniel G. (Norwick, VT), van Dijken, Johannes Pieter (Schiedam, NL), Shaw, IV, Arthur J. (Grantham, NH), Argyros, Aaron (White River Junction, VT), Barrett, Trisha (Bradford, VT), Caiazza, Nicky (Rancho Santa Fe, CA), Herring, Christopher D. (Lebanon, NH), Rogers, Stephen R. (Hanover, NH), Agbogbo, Frank (Lebanon, NH)
Mascoma Corporation (Lebanon NH)
14/ 348,231
September 28, 2012
STATEMENT REGARDING FEDERALLY-SPONSORED RESEARCH AND DEVELOPMENT [0001] This invention was funded, in part, by the United States government under a Department of Energy Biomass Program award # DE-FC36-07G017057. This invention was also funded, in part, by the BioEnergy Science Center (BESC) under the DOE Office of Science through award number DE-POS2-06ER64304. The U.S. Government has certain rights in this invention.