Methods of inducing protective hypothermia of an organ are described that include delivering a phase-change particulate slurry to at least a portion of the organ; and reducing a temperature of the organ through heat exchange with the phase-change particulate slurry. Therapeutically acceptable duration of artificially-induced ischemia of the organ is prolonged.
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
 This invention was made in part with Government support (Grant No. HL67630 awarded by the National Institutes of Health, and Contract No. W-31-109-ENG-38 between the U.S. Department of Energy and The University of Chicago representing Argonne National Laboratory). The Government may have certain rights in this invention.