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United States Patent Application

View the Complete Application at the US Patent & Trademark Office
A system and method for non-invasively tracking a particle in a sample is disclosed. The system includes a 2-photon or confocal laser scanning microscope (LSM) and a particle-holding device coupled to a stage with X-Y and Z position control. The system also includes a tracking module having a tracking excitation laser, X-Y and Z radiation-gathering components configured to detect deviations of the particle in an X-Y and Z directions. The system also includes a processor coupled to the X-Y and Z radiation gathering components, generate control signals configured to drive the stage X-Y and Z position controls to track the movement of the particle. The system may also include a synchronization module configured to generate LSM pixels stamped with stage position and a processing module configured to generate a 3D image showing the 3D trajectory of a particle using the LSM pixels stamped with stage position.
Yang, Haw (Princeton Junction, NJ), Welsher, Kevin (Plainsboro, NJ)
14/ 415,779
July 18, 2013
GOVERNMENT RIGHTS IN THIS INVENTION [0002] This invention was made with government support under Grant No. DE-SC0006838 awarded by the Department of Energy. The government has certain rights in this invention.