It has been identified in accordance with the present invention that Nell1 is essential for normal cardiovascular development by promoting proper formation of the heart and blood vessels. The present invention therefore provides therapeutic methods for treating cardiovascular disorders by employing a Nell1 protein or nucleic acid molecule.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH
 This invention was made with Government support under Contract No. DE-ACO5-000R22725 between the United States Department of Energy and UT-Battelle, LLC. The Government has certain rights in this invention.