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Biomarkers for Prediction of Response to PARP Inhibition in Breast Cancer

United States Patent Application

20140364434
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Methods and systems for identifying a cancer patient suitable for treatment with a PARP inhibitor. A 6-gene, 7-gene and 8-gene predictor panels of genes that are predictive of patient resistance or sensitivity to PARP inhibitors such as Olaparib.
Daeman, Anneleen (Pinole, CA), Wolf, Denise M. (Berkeley, CA), Van 't Veer, Laura J. (San Francisco, CA), Spellman, Paul T. (Portland, OR), Gray, Joe W. (Lake Oswego, OR)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
14/ 298,849
June 6, 2014
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy, and under UCSF Breast SPORE Bioinformatics Grant awarded by the National Cancer Institute/National Instituted of Health. The government has certain rights in the invention.