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COMPOSITIONS AND METHODS FOR THE RELIEF OF INHIBITION OF ALDEHYDE DECARBONYLASE

United States Patent Application

20140370563
A1
View the Complete Application at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
The present invention is related to compositions and methods for enhanced synthesis of hydrocarbons, particularly, but not limited to, alkanes. The invention, in one embodiment, utilizes the co-expression of a hydrogen peroxide metabolizing enzyme in the presence of an aldehyde decarbonylase enzyme to relieve hydrogen peroxide inhibition of the aldehyde decarbonylase enzyme by hydrogen peroxide. In a preferred embodiment a catalase-aldehyde decarbonylase expression construct and fusion peptide is used. The present invention also relates to microorganisms engineered to express said enzymes and to produce hydrocarbon molecules.
Shanklin, John (Shoreham, NY), Andre, Carl (Raleigh, NC)
BROOKHAVEN SCIENCE ASSOCIATES, LLC (Upton NY)
14/ 240,836
August 24, 2012
[0002] This invention was made with Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.