The present disclosure sets forth incorporating microfluidic chips Interfaces for use with digital microfluidic processes. Methods and devices according to the present disclosure utilize compact, integrated platforms that interface with a chip upstream and downstream of the reaction, as well as between intermediate reaction steps if needed. In some embodiments these interfaces are automated, including automation of a multiple reagent process. Various reagent delivery systems and methods are also disclosed.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT
 This invention was made with Government support of Grant Nos. DE-SC0001249 and DE-SC0005056, awarded by the U.S. Department of Energy. The Government has certain rights in this invention.