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United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
In one embodiment, a system includes a bioreactor coupled to a substrate. The bioreactor includes: a plurality of walls defining a reservoir; a plurality of fluidic channels in at least some of the walls; a fluidic inlet in fluidic communication with the reservoir via, the fluidic channels; a fluidic outlet in fluidic communication with the reservoir via the fluidic channels; and one or more sensors coupled to the reservoir, each sensor being configured to detect one or more of: environmental conditions in the reservoir; and physiological conditions of one or more cells optionally present in the reservoir. In another embodiment, a method includes delivering media to a reservoir of a bioreactor; delivering a, plurality of cells to the reservoir, controlling a reservoir temperature and a reservoir gas composition; using one or more of the sensors to monitor environmental and physiological conditions; and reporting the environmental and/or physiological conditions.
Sheth, Heeral (San Francisco, CA), Chen, Haiyin (San Ramon, CA), Hudson, Bryan D. (Livermore, CA), Kulp, Kris (Livermore, CA), Mcnerney, Margaret W. (Pleasanton, CA), Pannu, Satinderpall S. (Pleasanton, CA), Qian, Fang (Santa Cruz, CA), Tooker, Angela C. (Dublin, CA), Wheeler, Elizabeth K. (Livermore, CA)
Lawrence Livermore National Security, LLC (Livermore CA)
14/ 265,019
April 29, 2014
[0002] The United States Government has rights in this invention pursuant to Contract No. DE-AC52-07NA27344 between the United States Department of Energy and Lawrence Livermore National Security, LLC for the operation of Lawrence Livermore National Laboratory.