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METHOD OF IDENTIFYING SOLUBLE PROTEINS AND SOLUBLE PROTEIN COMPLEXES

United States Patent Application

20140024555
A1
View the Complete Application at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
Provided herein are methods of identifying a protein as soluble, as well as methods of identifying a soluble protein complex of at least two proteins. The methods allow for the determination of in vitro solubility, or both in vitro and in vivo solubility, of a protein or protein complex.
Waldo, Geoffrey S. (Santa Fe, NM), Lockard, Meghan A. (New York, NY)
LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos NM)
14/ 008,474
March 29, 2012
STATEMENT OF GOVERNMENT SUPPORT [0002] This invention was made with government support under Contract No. DE-AC52-06NA25396 awarded by the U.S. Department of Energy, and under the National Institutes of Health's Protein Structure Initiative, grant number 5U54GM074946-4. The government has certain rights in the invention.