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Elastic Modulus-modified MicroEnvironment microArrays (eMEArrays) and Uses Thereof

United States Patent Application

20130324439
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A combinatorial elastic modulus-modified microenvironment microarray (eMEArray) platform and methods for cell-based functional screening of interactions with combinatorial microenvironments. The platform and methods allow for simultaneous control of the molecular composition and the elastic modulus, and combines the use of microarray and micropatterning technologies. The eMEArrays have been used to show that the microenvironment has effects on drug-cell interactions and contributes to therapeutic response.
LaBarge, Mark A. (Orinda, CA), Lin, Chun-Han (Berkeley, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
13/ 911,012
June 5, 2013
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This invention was made with government support under Grant Numbers AG033176 and AG040081 awarded by the National Institute on Aging and by Laboratory Directed Research and Development and Contract No. DE-ACO2-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.