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PRODUCTION OF POLYHYDROXYALKANOATES WITH A DEFINED COMPOSITION FROM AN UNRELATED CARBON SOURCE

United States Patent Application

20140073022
A1
View the Complete Application at the US Patent & Trademark Office
Cells and methods for producing polyhydroxyalkanoates. The cells comprise one or more recombinant genes selected from an R-specific enoyl-CoA hydratase gene, a PHA polymerase gene, a thioesterase gene, and an acyl-CoA-synthetase gene. The cells further have one or more genes functionally deleted. The functionally deleted genes include such genes as an enoyl-CoA hydratase gene, a 3-hydroxyacyl-CoA dehydrogenase, and a 3-ketoacyl-CoA thiolase gene. The recombinant cells are capable of using producing polyhydroxyalkanoates with a high proportion of monomers having the same carbon length from non-lipid substrates, such as carbohydrates.
PFLEGER, BRIAN FREDERICK (MADISON, WI), AGNEW, DANIEL E. (MADISON, WI)
WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON WI)
13/ 833,230
March 15, 2013
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH [0002] This invention was made with government support under DE-FC02-07ER64494 awarded by the US Department of Energy. The government has certain rights in the invention.