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Flow method and apparatus for screening chemicals using micro x-ray fluorescence

United States Patent Application

20050214847
A1
View the Complete Application at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
Flow method and apparatus for screening chemicals using micro x-ray fluorescence. The invention includes a method and apparatus for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder. According to the method, after preparing a solution of potential pharmaceutical chemicals with at least one target binder, the solution is flow-separated into at least two separated components. Each component is exposed to an x-ray excitation beam. Any component that emits a detectable x-ray fluorescence signal is isolated.
Havrilla, George J. (Los Alamos, NM), Miller, Thomasin C. (Los Alamos, NM), Warner, Benjamin P. (Los Alamos, NM), Lewis, Cris L. (Los Alamos, NM), Mahan, Cynthia A. (Los Alamos, NM), Wells, Cyndi A. (Los Alamos, NM)
The Regents of the University of California
11/ 125,036
May 9, 2005
[0001] This invention was made with government support under Contract No. W-7405-ENG-36 awarded by the U.S. Department of Energy. The government has certain rights in the invention.