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High throughput screening using fluorophore labeled lipid membranes and fluorescence correlation spectroscopy

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
An apparatus for and method of detecting a binding event between biomolecules is disclosed and includes admixing a target molecule including a first fluorophore and membrane vesicles including a trifunctional linker molecule, said trifunctional linker molecule including a second fluorophore, to form a sample, introducing a library of elements into said sample, each of said library elements having a binding affinity for said trifunctional linker molecule, and, screening said sample for fluorescence from said first fluorophore and said second fluorophore, such fluorescence indicative of a binding event between an element from said library of elements and said target molecule.
Werner, James H. (Los Alamos, NM), Reed, Scott M. (Portland, OR), Swanson, Basil I. (Los Alamos, NM)
10/ 790,638
March 1, 2004
[0001] This invention was made with government support under Contract No. W-7405-ENG-36 awarded by the U.S. Department of Energy. The government has certain rights in the invention.