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Dynamic Assay for Maintenance and Disruption of Tissue Level Organization and Architecture

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A micropatterning approach, systems and methods that confine cells to a specified geometry combined with an algorithm to quantify changes of cellular distribution over time to measure the ability of different cell types to self-organize relative to each other and detect loss of cellular self-organization.
LaBarge, Mark A. (Orinda, CA), Bissell, Mina J. (Berkeley, CA), Stampfer, Martha R. (Oakland, CA)
13/ 762,309
February 7, 2013
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy, under Grant No. R00AG033176 from the National Institute on Aging, Grant U54CA112970 from the National Cancer Institute, and by Laboratory Directed Research and Development (LDRD) funding from the Lawrence Berkeley National Laboratory, provided by the Director, Office of Science, of the US Department of Energy under Contract DE-AC02-05CH11231, by National Cancer Institute Grants R37CA064786, U54CA126552, R01CA057621, U54CA112970, U54CA143836, and U01CA143233; and by US Department of Defense Grants W81XWH0810736, BCRP BC060444 and U54CA112970. The government has certain rights in the invention.