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Boron-Based Dual Imaging Probes, Compositions and Methods for Rapid Aqueous F-18 Labeling, and Imaging Methods Using Same

United States Patent Application

20130189185
A1
View the Complete Application at the US Patent & Trademark Office
A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: ##STR00001## wherein R.sub.1-R.sub.7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.
LI, Zibo (San Gabriel, CA), GABBAI, Francois P. (College Station, TX), CONTI, Peter S. (Pasadena, CA), HUDNALL, Todd W. (College Station, TX), LIN, Tzu-Pin (College Station, TX), LIU, Shuanglong (Alhambra, CA), HUANG, Chiun-Wei (Alhambra, CA)
UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles CA)
13/ 549,309
July 13, 2012
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0001] This invention was made with government support under Contract No. DE-SC0002353 awarded by the Department of Energy, Contract No. P30CA014089 awarded by the National Cancer Institute, and contract No. CHE-0952912 awarded by the National Science Foundation. The government has certain rights in the invention.