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IDENTIFICATION OF INVASIVE AND SLOW-GROWING TUMORIGENIC CELL SUBSETS IN TUMORS

United States Patent Application

20130157285
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
HA-based functional probes and a multiplexed targeting strategy for detection and isolation of invasive subpopulations in breast cancer cell lines. Methods for using HA metabolism for profiling and sorting breast cancer heterogeneity. As such, HA-based functional probes have appropriate targeting capacity and safety profiles for development as imaging and therapeutic agents for following repair and neoplastic disease processes such as breast cancer.
Veiseh, Mandana (Emeryville, CA), Turley, Eva A. (London, CA), Bissell, Mina J. (Berkeley, CA)
The Regents of the University of California (Oakland CA)
13/ 651,381
October 12, 2012
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy Office of Biological and Environmental Research and Low Dose Radiation Program; under Grant F32 CA132491 awarded by the National Cancer Institute of the NIH: under awards R37CA064786, U54CA126552, R01CA057621, U54CA112970, U01CA143233, and U54CA143836 awarded by the National Cancer Institute of the NIH; and the DOD-BCRP IDEA Grant W81XWH0810736 awarded by the U.S. Department of Defense. The government has certain rights in the invention.