HA-based functional probes and a multiplexed targeting strategy for detection and isolation of invasive subpopulations in breast cancer cell lines. Methods for using HA metabolism for profiling and sorting breast cancer heterogeneity. As such, HA-based functional probes have appropriate targeting capacity and safety profiles for development as imaging and therapeutic agents for following repair and neoplastic disease processes such as breast cancer.
STATEMENT OF GOVERNMENTAL SUPPORT
 This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy Office of Biological and Environmental Research and Low Dose Radiation Program; under Grant F32 CA132491 awarded by the National Cancer Institute of the NIH: under awards R37CA064786, U54CA126552, R01CA057621, U54CA112970, U01CA143233, and U54CA143836 awarded by the National Cancer Institute of the NIH; and the DOD-BCRP IDEA Grant W81XWH0810736 awarded by the U.S. Department of Defense. The government has certain rights in the invention.