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Long-Range Barcode Labeling-Sequencing

United States Patent Application

*** PATENT GRANTED ***
20130130919
9,469,874
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Methods for sequencing single large DNA molecules by clonal multiple displacement amplification using barcoded primers. Sequences are binned based on barcode sequences and sequenced using a microdroplet-based method for sequencing large polynucleotide templates to enable assembly of haplotype-resolved complex genomes and metagenomes.
CHEN, Feng (Castro Valley, CA), Zhang, Tao (San Diego, CA), Singh, Kanwar K. (Pittsburg, CA), Pennacchio, Len A. (Sebastopol, CA), Froula, Jeff L. (Walnut Creek, CA), Eng, Kevin S. (San Francisco, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
13/ 653,343
October 16, 2012
STATEMENT REGARDING GOVERNMENTAL SUPPORT [0002] This invention was made with Government support under Contract No. DE-AC02-05CH11231 awarded by the Department of Energy. The Government has certain rights in the invention.