Embodiments of a method to use nucleic acid oligomer sequences for modulating the shape of nanoparticles are disclosed, as well as nanoparticles and methods of using the nanoparticles. Systematic variations of the nucleic acid sequences offer mechanistic insights into the morphology control. A plurality of nucleic acid oligomers is adsorbed onto a metal nanoseed to provide an oligomer-functionalized nanoparticle. Additional metal is deposited onto the oligomer-functionalized nanoparticle to produce a shaped nanoparticle having a morphology based at least in part on the nanoseed morphology and the oligomer's sequence composition. Embodiments of methods for using the shaped nanoparticles also are disclosed.
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT
 This invention was made with government support under Grant Nos. CMMI0749028, CTS0120978, and DMR0117792 awarded by the National Science Foundation, and DEFG02-91-ER45439, awarded by the U.S. Department of Energy. The government has certain rights in the invention.