
Forming an Artificial Cell with controlled membrane composition, asymmetry, and contents
United States Patent Application
20130028963 | |
A1 | |
View the Complete Application at the US Patent & Trademark Office | |
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website | |
The present invention provides a vesicle having a unilamellar bilayer including a lipid and a second bilayer component selected from a membrane protein or a functionalized lipid. The vesicle also includes a component encapsulated by the unilamellar bilayer, wherein the encapsulated component includes a protein, a peptide, an enzyme, an oligonucleotide, or a polynucleotide. Also included are methods of making the vesicles of the present invention. | |
Fletcher, Daniel A. (Berkeley, CA), Li, Thomas (Modesto, CA), Parekh, Sapun (Washington, DC), Stachowiak, Jeanne (Oakland, CA), Liu, Allen (San Diego, CA), Richmond, David (Berkeley, CA), Schmid, Eva (San Francisco, CA) | |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA) | |
13/ 631,087 | |
September 28, 2012 | |
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This work was supported by the Nanomedicine Development Center Grant No. 10986-31150-44-IQDAF awarded by the National Institutes of Health, and under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in this invention. |