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Forming an Artificial Cell with controlled membrane composition, asymmetry, and contents

United States Patent Application

20130028963
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides a vesicle having a unilamellar bilayer including a lipid and a second bilayer component selected from a membrane protein or a functionalized lipid. The vesicle also includes a component encapsulated by the unilamellar bilayer, wherein the encapsulated component includes a protein, a peptide, an enzyme, an oligonucleotide, or a polynucleotide. Also included are methods of making the vesicles of the present invention.
Fletcher, Daniel A. (Berkeley, CA), Li, Thomas (Modesto, CA), Parekh, Sapun (Washington, DC), Stachowiak, Jeanne (Oakland, CA), Liu, Allen (San Diego, CA), Richmond, David (Berkeley, CA), Schmid, Eva (San Francisco, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
13/ 631,087
September 28, 2012
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This work was supported by the Nanomedicine Development Center Grant No. 10986-31150-44-IQDAF awarded by the National Institutes of Health, and under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in this invention.