Provided herein are skin-mounted biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided, including electronic devices useful for establishing conformal contact with the skin of a subject. Devices disclosed herein can comprise a plurality of sensing and/or actuating devices provided as part of a skin-mounted flexible or stretchable electronic circuit.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
 This invention was made with United States governmental support from the U.S. Department of Energy under Award No. DEFG02-91ER45439, the National Science Foundation under grant DMI-0328162, the U.S. Department of Energy under Award No. DE-FG02-07ER46453 and DE-FG02-07ER46471, the U.S. Army Research Laboratory and the U.S. Army Research Office under contract number W911 NF-07-1-0618, the National Institute of Neurological Disorders and Stroke (NINDS) under Award Nos. RO1-NS041811-04 and RO1-NS48598-01 and by the DARPA-DSO and the National Institutes of Health P41 Tissue Engineering Resource Center under award number P41 EB002520. The U.S. Government has certain rights in the invention.