Methods and compositions for using 14-3-3sigma gene and protein as a highly sensitive and specific basal breast cancer biomarker, which when present, correlates with metastasis and poor outcome in independent patient cohorts. Methods and compositions for targeting 14-3-3sigma-regulated actin cytoskeletal interactions, activity and function may benefit patients having the basal-like breast cancer subtype.
STATEMENT OF GOVERNMENTAL SUPPORT
 This work was supported by Grant No. W81XWH-05-1-0339 awarded by Department of Defense Breast Cancer Research Program; and by Contract No. DE-AC02-05CH11231 awarded by the Department of Energy. The government has certain rights in this invention.