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14-3-3 sigma as a Biomarker of Basal Cancer

United States Patent Application

20120329663
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Methods and compositions for using 14-3-3sigma gene and protein as a highly sensitive and specific basal breast cancer biomarker, which when present, correlates with metastasis and poor outcome in independent patient cohorts. Methods and compositions for targeting 14-3-3sigma-regulated actin cytoskeletal interactions, activity and function may benefit patients having the basal-like breast cancer subtype.
Boudreau, Aaron T. (Berkeley, CA), Bissell, Mina J. (Berkeley, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
13/ 330,467
December 19, 2011
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This work was supported by Grant No. W81XWH-05-1-0339 awarded by Department of Defense Breast Cancer Research Program; and by Contract No. DE-AC02-05CH11231 awarded by the Department of Energy. The government has certain rights in this invention.