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Method for Making Mate-Pair Libraries

United States Patent Application

20120329678
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present disclosure provides methods for generating mate-pair libraries using a recombinase/recombination site system. The method allows for increased insert size, improved efficiency and simplicity of the steps involved, and improved data generation. Mate-pair libraries are helpful in providing positional information for the assembly of sequence data from short read sequencing platforms. The disclosure also embodies the mate-pair libraries as generated from these methods.
Chen, Feng (Castro Valley, CA), Peng, Ze (Moraga, CA), Zhao, Zhiying (Danville, CA), Nath, Nandita (Fremont, CA), Froula, Jeff L. (Walnut Creek, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
13/ 535,167
June 27, 2012
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention described and claimed herein was supported by Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy under. The government has certain rights in the invention.