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INTEGRATED MICROFLUIDICS FOR HIGHLY PARALLEL SCREENING OF CHEMICAL REACTIONS

United States Patent Application

20120309648
A1
View the Complete Application at the US Patent & Trademark Office
A microfluidic system has a microfluidic mixer and a sample storage component that is in fluid connection with the microfluidic mixer. The microfluidic mixer has a mixing section; a target molecule input section that is in fluid connection with the mixing section, the target molecule input section being suitable to provide a fluid into the mixing section that contains molecules to be targeted by chemical reactions; a first reagent input section that is in fluid connection with the mixing section, the first reagent input section being structured to selectively provide a first reagent selected from a plurality of reagents to test a chemical reaction with the target molecules; a second reagent input section that is in fluid connection with the mixing section, the second reagent input section being structured to selectively provide a second reagent selected from a plurality of reagents to test a chemical reaction with the target molecules and said first reagent; and a neutral fluid input section that is in selectable fluid connection with the sample storage component, the neutral fluid input section being structured to selectively provide a neutral fluid into the sample storage component between successive samples provided to the sample storage component to separate successive samples in a stratified arrangement.
Tseng, Hsian-Rong (Los Angeles, CA), Wang, Jinyi (Los Angeles, CA), Sui, Guodong (Los Angeles, CA), Faull, Kym F. (Los Angeles, CA), Wang, Yanju (Los Angeles, CA), Lin, Wei-Yu (Los Angeles, CA)
The Regents of the University of Calfornia (Oakland CA)
12/ 667,861
July 7, 2008
[0002] The U.S. Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of Grant No. DEFG0206ER64294, awarded by the Department of Energy, and of Grant No. 1 U54 CA119347-01, awarded by the National Institutes of Health.