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Microfluidic integrated microarrays for biological detection

United States Patent Application

20050095602
A1
View the Complete Application at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
Disclosed are microflulidic chips that include a plurality of vias; a functionalized porous polymer monolith capable of being in fluid communication with a via; a microarray capable of being in fluid communication with the functionalized porous polymer monolith; and an observation port through which at least one target disposed within the microarray is capable of being detected. The disclosed microfluidic chips contain microarrays that can be effectively coupled to functionalized porous polymer monoliths for capturing and concentrating sample nucleic acids. Also disclosed are microfluidic chips containing microarray probes having observation ports that enable the preparation of microarrays and the detection of targets. These microfluidic chips are capable of capturing and concentrating genetic material for the analysis and identification of biological organisms, such as so-called "threat genes" from chimeric bioweapons.
West, Jason A.A. (Castro Valley, CA), Shepodd, Timothy J. (Livermore, CA), Griffiths, Stewart K. (Livermore, CA), Renzi, Ronald F. (Tracy, CA), Wiedenman, Boyd J. (Alpharetta, GA)
10/ 701,097
November 4, 2003
[0001] This invention is made with Government support under contract no. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention.