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METHODS FOR MODULATING BACTERIAL INFECTION

United States Patent Application

20120276149
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria. More particularly, the present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria of the gastrointestinal (GI) tract. The present invention further relates to methods for promoting pathways induced by commensal bacteria of the GI tract that lead to Th17 differentiation, which in turn leads to localized and systemic accumulation of Th17 cells. Compositions and medicaments are also described herein that are used alleviate and/or prevent symptoms associated with diseases caused by or associated with pathogenic bacteria. Accordingly, the compositions, medicaments and methods described herein may be used to address the needs of patients or subjects that would benefit from increased Th17 cell differentiation.
Littman, Dan (New York, NY), Ivanov, Ivaylo (New York, NY), Brodie, Eoin (Piedmont, CA), Umesaki, Yoshinori (Kunitachi-shi, JP), Honda, Kenya (Toshima-ku, JP)
13/ 501,615
October 15, 2010
GOVERNMENTAL SUPPORT [0001] The research leading to the present invention was funded in part by National Institutes of Health Grant No. AI33856 and under the auspices of the United States Department of Energy under contract DEAC02-05CH11231. Accordingly, the United States government has certain rights in the invention.