This invention provides targeted nanoclusters comprising multiple polyvalent nanoparticle core units or nanoscaffolds, each nanoparticle core unit attached to multiple targeting moieties and multiple detectable moieties. The nanoclusters find use in a broad range of analytical assays, diagnostic assays and as targeted therapeutics.
STATEMENT OF GOVERNMENTAL SUPPORT
 This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the Department of Energy and LG013 Agilent Foundation Gift. The government has certain rights to this invention.