Skip to Content
Find More Like This
Return to Search

MICROFLUIDIC PLATFORM FOR SYNTHETIC BIOLOGY APPLICATIONS

United States Patent Application

20120258487
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
This invention provides methods and compositions for assembling biological constructs (e.g., plasmids, transformed cells, etc.). In certain embodiments the methods involve encapsulating separate components of said biological construct each in a fluid droplet confined in a fluid channel; optionally mixing droplets from different fluid channels to for a sequenced order of droplets carrying different components of said biological construct in a channel or chamber; and optionally combining two or more droplets each containing different components of said biological construct to permit said components to react with each other in one or more reactions contributing to the assembly of said biological construct.
Chang, Chieh (San Jose, CA), Bharadwaj, Rajiv (Emeryville, CA), Singh, Anup K. (Danville, CA), Chandrasekaran, Aarthi (San Jose, CA), Hillson, Nathan J. (San Francisco, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA), SANDIA CORPORATION (Livermore CA)
13/ 437,727
April 2, 2012
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in this invention.