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Ultrasensitive Biochemical Sensing Device and Method of Sensing Analytes

United States Patent Application

*** PATENT GRANTED ***
20120238471
9,671,327
A1
View the Complete Application at the US Patent & Trademark Office
Systems and methods biochemically sense a concentration of a ligand using a sensor having a substrate having a metallic nanoparticle array formed onto a surface of the substrate. A light source is incident on the surface. A matrix is deposited over the nanoparticle array and contains a protein adapted to binding the ligand. A detector detects s-polarized and p-polarized light from the reflective surface. Spacing of nanoparticles in the array and wavelength of light are selected such that plasmon resonance occurs with an isotropic point such that -s and -p polarizations of the incident light result in substantially identical surface Plasmon resonance, wherein binding of the ligand to the protein shifts the resonance such that differences between the -S and -P polarizations give in a signal indicative of presence of the ligand.
Pinchuk, Anatoliy (Colorado Springs, CO)
13/ 422,718
March 16, 2012
GOVERNMENT INTEREST [0002] This invention was made with government support under grant number DE-AC02-06CH11357 awarded by the U.S. Department of Energy. The government has certain rights in the invention.