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Combination Treatment of Hydroxpyridonate Actinide/Lanthanide Decorporation Agents

United States Patent Application

20120214843
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The invention provides for a method for treating a subject in need of such treatment comprising administering a therapeutically effective amount of one or more pharmaceutical compositions comprising a 1,2-HOPO chelating agent and a 3,2-HOPO chelating agent to a subject in need of such treatment. The use of both 1,2-HOPO and a 3,2-HOPO chelating agents in combination is more effective than using only one chelating agent alone. The invention is especially useful when practiced on a subject that has been exposed to, have been in contact with, or contaminated by one or more known or unknown actinides and/or lanthanides, or a mixture thereof.
Durbin-Heavey, Patricia W. (Oakland, CA), Heavey, Leonore Frances (Baton Rouge, LA), Raymond, Kenneth N. (Berkeley, CA), Abergel, Rebecca J. (Berkeley, CA), Shuh, David K. (Oakland, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
13/ 291,383
November 8, 2011
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy and Grant No. 1R01A1074065-01 awarded by the National Institutes of Health. The government has certain rights in the invention.