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Combination Treatment of Hydroxpyridonate Actinide/Lanthanide Decorporation Agents

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The invention provides for a method for treating a subject in need of such treatment comprising administering a therapeutically effective amount of one or more pharmaceutical compositions comprising a 1,2-HOPO chelating agent and a 3,2-HOPO chelating agent to a subject in need of such treatment. The use of both 1,2-HOPO and a 3,2-HOPO chelating agents in combination is more effective than using only one chelating agent alone. The invention is especially useful when practiced on a subject that has been exposed to, have been in contact with, or contaminated by one or more known or unknown actinides and/or lanthanides, or a mixture thereof.
Durbin-Heavey, Patricia W. (Oakland, CA), Heavey, Leonore Frances (Baton Rouge, LA), Raymond, Kenneth N. (Berkeley, CA), Abergel, Rebecca J. (Berkeley, CA), Shuh, David K. (Oakland, CA)
13/ 291,383
November 8, 2011
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy and Grant No. 1R01A1074065-01 awarded by the National Institutes of Health. The government has certain rights in the invention.