The disclosure provides a field-effect transistor (FET)-based biosensor and uses thereof. In particular, to FET-based biosensors using thermally reduced graphene-based sheets as a conducting channel decorated with nanoparticle-biomolecule conjugates. The present disclosure also relates to FET-based biosensors using metal nitride/graphene hybrid sheets. The disclosure provides a method for detecting a target biomolecule in a sample using the FET-based biosensor described herein.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH
 This invention was made with government support under CMMI-0900509, CBET-0803142, and ECCS-0708998 awarded by the National Science Foundation and DE-EE003208 awarded by the Department of Energy. The United States government has certain rights in the invention.