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Plasmonic System for Detecting Binding of Biological Molecules

United States Patent Application

20120208174
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Detection and characterization of molecular interactions on membrane surfaces is important to biological and pharmacological research. In one embodiment, silver nanocubes interfaced with glass-supported model membranes form a label-free sensor that measures protein binding to the membrane. The present device and technique utilizes plasmon resonance scattering of nanoparticles, which are chemically coupled to the membrane. In contrast to other plasmonic sensing techniques, this method features simple, solution-based device fabrication and readout. Static and dynamic protein/membrane binding are monitored and quantified.
Galush, William J. (Redwood City, CA), Shelby, Sarah A. (Ithaca, NY), Mulvihill, Martin J. (Oakland, CA), Tao, Andrea R. (La Jolla, CA), Yang, Peidong (Kensington, CA), Groves, John T. (Berkeley, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
13/ 204,506
August 5, 2011
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.