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Spatial Biomarker of Disease and Detection of Spatial Organization of Cellular Receptors

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened for therapeutic potential in the assay: a potentially efficacious drug is identified by an ability to modulate an established signature. The receptor distribution signature can be corroborated with an mRNA expression profile of several genes, indicating, for example, metastasis.
Salaita, Khalid S. (Decatur, GA), Nair, Pradeep M. (Berkeley, CA), Das, Debopriya (Albany, CA), Gray, Joe W. (San Francisco, CA), Groves, John T. (Berkeley, CA)
13/ 194,577
July 29, 2011
STATEMENT OF GOVERNMENTAL SUPPORT [0003] This work was supported by Contract No. DE-AC02-05CH11231 awarded by the Department of Energy, by U.S. Department of Defense Breast Cancer Research Program Concept Award BC076701 under U.S. Army Medical Research Acquisition Activity No. W81XWH-08-1-0677, and by grants P50 CA 58207, and by the U54 CA 112970 awarded by the National Institutes of Health, National Cancer Institute. The government has certain rights in the invention.