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INFECTION DETECTION METHODS AND SYSTEMS AND RELATED COMPOUNDS AND COMPOSITIONS

United States Patent Application

20120122079
A1
View the Complete Application at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
A compound, or a pharmaceutically acceptable salt, ester, hydrate or solvate thereof, comprising formula IV: A-B wherein A comprises a substrate for an enzyme of a microorganism; B comprises an odorant moiety; B is covalently bonded to an anomeric carbon of A; and A is enzymatically cleavable from B at the covalent bond site between A and B by the enzyme of the microorganism. Examples of such compounds are referred to as substrate-odorant compounds or odorant chimeras. Also disclosed are methods for detecting a microorganism that include contacting the compound with a sample that may include the microorganism.
Schmidt, Jurgen G. (Los Alamos, NM), Wolfenden, Mark (Los Alamos, NM), Anderson, Aaron (Los Alamos, NM), Harris, Jennifer Foster (Los Alamos, NM), Koglin, Alexander (Santa Fe, NM)
Los Alamos National Security, LLC
13/ 294,963
November 11, 2011
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT [0002] This invention was made with government support under Contract No. DE-AC52-06NA25396 between the United States Department of Energy and Los Alamos National Security, LLC for the operation of Los Alamos National Laboratory. The U.S. Government has certain rights in the invention.