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BAIT CHEMISTRIES IN HYDROGEL PARTICLES FOR SERUM BIOMARKER ANALYSIS

United States Patent Application

20120107959
A1
View the Complete Application at the US Patent & Trademark Office
This invention describes the identification of novel organic dye chemistries that can be used as affinity baits to capture proteins and other biomolecules useful in the fields of medical diagnostics, environmental science, toxicology, and infectious disease. Incorporation of unique affinity dye compounds within hydrogel capture particles improves analyte yield and preanalytical precision, and stabilizes the analyte against degradation, while increasing measurement sensitivity. The particles in this invention can be used for routine clinical testing as well as for discovery of low abundance disease biomarkers. Example hydrogel particles containing new high affinity bait chemistries were used to identify a new set of human serum biomarkers.
Liotta, Lance (Bethesda, MD), Espina, Virginia (Rockville, MD), Luchini, Alessandra (Burke, VA), Tamburro, Davide (Bristow, VA)
13/ 379,345
June 21, 2010
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT [0002] This invention was made with Government support under Grant No. DE-FC52-04NA25455, awarded by the Department of Energy. The government has certain rights in the invention.