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Photoacoustic removal of occlusions from blood vessels

United States Patent Application

20050021013
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamic flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombi and emboli) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photoacoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamic flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.
Visuri, Steven R. (Livermore, CA), Da Silva, Luiz B. (Danville, CA), Celliers, Peter M. (Berkelley, CA), London, Richard A. (Orinda, CA), Maitland, Duncan J. IV (Lafayette, CA), Esch, Victor C. (San Francisco, CA)
Endo Vasix, Inc.
10/ 241,741
September 10, 2002
[0001] The United States Government has, rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.