Compositions containing an optionally surface-functionalized mesoporous support and a biologically active agent, and pharmaceutical compositions of the same, are provided herein. Such compositions can be useful in the treatment of tumors, for example, by injection of the composition at a location near the site of the tumor.
STATEMENT OF GOVERNMENT SUPPORT
 The invention described herein was made in part with government support under grant numbers R01GM080987 and R01CA134487, each awarded by the National Institutes of Health; as well as funds provided under Contract DE-AC0576RL01830 awarded by the U.S. Department of Energy. The Government has certain rights in the invention.