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CELLS WITH NON-NATURAL PHYSIOLOGIES DERIVED BY EXPRESSING LIGHT-POWERED PROTON PUMPS IN ONE OR MORE MEMBRANES

United States Patent Application

20110256605
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Methods and procedures for designing and constructing microbes with the ability to harvest light energy are described. In certain embodiments, these methods and procedures are used to construct a photosynthetic yeast based on proteorhodopsin (PR) expression. Proteorhodopsin is a light powered proton pump used by some ocean bacteria to scavenge light energy. By illuminating single yeast cells expressing PR, controlled amounts of energy can be delivered to these cells. A light-harvesting yeast is a unique bioenergetics research platform for investigating the interplay of biofuel production, cellular ATP levels, and the proton-motive-force (pmf). Also, a strain of yeast with light-boosted biomass to biofuel conversion efficiency possesses direct industrial and commercial utility.
Liphardt, Jan T. (Berkeley, CA), Walter, Jessica M. (Albany, CA), Rine, Jasper (Richmond, CA), Bustamante, Carlos (Berkeley, CA)
The Regents of the University of California, a California corporation (Oakland CA)
13/ 044,728
March 10, 2011
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This work was supported in part by Contract No. DE-AC02-05CH11231 awarded by the US Department of Energy. The U.S. government has certain rights in the invention.